Cellular mechanism of bile acid-accelerated hepatocyte polarity.

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Small GTPases. 2011 Nov 1;2(6):314-317. doi: 10.4161/sgtp.18087

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Cellular mechanism of bile acid-accelerated hepatocyte polarity. Lippincott-Schwartz Lab

Fu D, Lippincott-Schwartz J, Arias IM

Note: Research in this publication was not performed at Janelia.

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Abstract

We recently discovered that the major mammalian bile acid, taurocholate, accelerated polarity in primary rat hepatocytes. Taurocholate increased cellular cAMP and signals through an Epac-Rap1-MEK-LKB1-AMPK pathway for its polarity effect. This review discusses possible mechanisms for how taurocholate affects different cell polarity factors, particularly AMPK, and thereby regulates events that generate polarity. These include tight junction formation, apical trafficking, recycling endosome dynamics, and cytoskeleton rearrangement. We also discuss whether the effects of taurocholate are mediated by other LKB1 downstream kinases, such as Par1 and NUAK1.

PMID: 22545229 [PubMed - indexed for MEDLINE]

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Cellular mechanism of bile acid-accelerated hepatocyte polarity.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 22545229 [PubMed - indexed for MEDLINE]

Janelia Authors