Complex wavefront corrections for deep tissue focusing using low coherence backscattered light.

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Optics Express. 2012;20(15):16532-43. doi: 10.1364/OE.20.016532

Selected by the Editors for publication on the Virtual Journal for Biomedical Optics

Complex wavefront corrections for deep tissue focusing using low coherence backscattered light. Cui Lab

Fiolka R, Si K, Cui M

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Abstract

Aberrations and random scattering severely limit optical imaging in deep tissue. Adaptive optics can in principle drastically extend the penetration depth and improve the image quality. However, for random scattering media a large number of spatial modes need to be measured and controlled to restore a diffraction limited focus. Here, we present a parallel wavefront optimization method using backscattered light as a feedback. Spatial confinement of the feedback signal is realized with a confocal pinhole and coherence gating. We show in simulations and experiments that this approach enables focusing deep into tissue over up to six mean scattering path lengths. Experimentally the technique was tested on tissue phantoms and fixed brain slices.

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Complex wavefront corrections for deep tissue focusing using low coherence backscattered light.

Abstract