Droplet freezing, docking, and the exchange of immiscible phase and surfactant around frozen droplets.

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Lab Chip. 2010 Jul;10(14):1873-7. doi: 10.1039/c001108h

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Droplet freezing, docking, and the exchange of immiscible phase and surfactant around frozen droplets. Sgro Lab

Sgro AE, Chiu DT

Note: Research in this publication was not performed at Janelia.

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Abstract

This paper describes a platform for cooling microfluidic chips so as to freeze aqueous droplets flowing in oil. Using a whole-chip cooling chamber, we can control the ambient temperature surrounding a microfluidic chip and induce cooling and freezing inside the channels. When combined with a droplet generation and droplet docking chip, this platform allows for the facile freezing of droplets immobilized in resistance-based docks. Depending on the design and shape of the docks, the frozen droplets can either be trapped stably in the docks or be released because deformed non-frozen aqueous droplets turn spherical when frozen, and thus can become dislodged from the docks. Additionally, using this chamber and chip combination we are able to exchange immiscible phases and surfactants surrounding the frozen droplets. The materials and methods are inexpensive and easily accessible to microfluidics researchers, making this a simple addition to an existing microfluidic platform.

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Droplet freezing, docking, and the exchange of immiscible phase and surfactant around frozen droplets.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 20467690 [PubMed - indexed for MEDLINE]

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