Dystroglycan is a scaffold for extracellular axon guidance decisions.

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eLife. 2019 Feb 13;8. doi: 10.7554/eLife.42143

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Dystroglycan is a scaffold for extracellular axon guidance decisions. Gene Targeting and Transgenics

Lindenmaier LB, Parmentier N, Guo C, Tissir F, Wright KM

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Abstract

Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear. Here we show that the transmembrane glycoprotein Dystroglycan interacts with a changing set of environmental cues that regulate the trajectories of extending axons throughout the mammalian brain and spinal cord. Dystroglycan operates primarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and does not require signaling through its intracellular domain. We identify the transmembrane receptor Celsr3/Adgrc3 as a binding partner for Dystroglycan, and show that this interaction is critical for specific axon guidance events . These findings establish Dystroglycan as a multifunctional scaffold that coordinates extracellular matrix proteins, secreted cues, and transmembrane receptors to regulate axon guidance.

PMID: 30758284 [PubMed - indexed for MEDLINE]

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Dystroglycan is a scaffold for extracellular axon guidance decisions.

Abstract

PMID: 30758284 [PubMed - indexed for MEDLINE]

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