Main Menu (Mobile)- Block

Main Menu - Block

Extremes of lineage plasticity in the Drosophila brain.

Our Research / Publications
janelia7_blocks-janelia7_biblio_header | block
Current Biology. 2013 Sep 19;23(19):1908-13. doi: 10.1016/j.cub.2013.07.074
View Article on
Extremes of lineage plasticity in the Drosophila brain. Truman Lab
Lin S, Marin EC, Yang C, Kao C, Apenteng BA, Huang Y, O’Connor MB, Truman JW, Lee T
janelia7_blocks-janelia7_biblio_abstract | block

Abstract

An often-overlooked aspect of neural plasticity is the plasticity of neuronal composition, in which the numbers of neurons of particular classes are altered in response to environment and experience. The Drosophila brain features several well-characterized lineages in which a single neuroblast gives rise to multiple neuronal classes in a stereotyped sequence during development [1]. We find that in the intrinsic mushroom body neuron lineage, the numbers for each class are highly plastic, depending on the timing of temporal fate transitions and the rate of neuroblast proliferation. For example, mushroom body neuroblast cycling can continue under starvation conditions, uncoupled from temporal fate transitions that depend on extrinsic cues reflecting organismal growth and development. In contrast, the proliferation rates of antennal lobe lineages are closely associated with organismal development, and their temporal fate changes appear to be cell cycle-dependent, such that the same numbers and types of uniglomerular projection neurons innervate the antennal lobe following various perturbations. We propose that this surprising difference in plasticity for these brain lineages is adaptive, given their respective roles as parallel processors versus discrete carriers of olfactory information.

PMID: 24055154 [PubMed - indexed for MEDLINE]

node:body | entity_field
janelia7_blocks-janelia7_biblio_authors | block

Janelia Authors

Jim Truman
Tzumin Lee
janelia7_blocks-janelia7_biblio_tools | block