Innexin expression in electrically coupled motor circuits

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Neuroscience Letters. 2019 Mar 16;695:19-24. doi: https://doi.org/10.1016/j.neulet.2017.07.016

Innexin expression in electrically coupled motor circuits Otopalik Lab

Otopalik Adriane, Lane Brian, Schulz David, Marder Eve

Note: Research in this publication was not performed at Janelia.

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Abstract

The many roles of innexins, the molecules that form gap junctions in invertebrates, have been explored in numerous species. Here, we present a summary of innexin expression and function in two small, central pattern generating circuits found in crustaceans: the stomatogastric ganglion and the cardiac ganglion. The two ganglia express multiple innexin genes, exhibit varying combinations of symmetrical and rectifying gap junctions, as well as gap junctions within and across different cell types. Past studies have revealed correlations in ion channel and innexin expression in coupled neurons, as well as intriguing functional relationships between ion channel conductances and electrical coupling. Together, these studies suggest a putative role for innexins in correlating activity between coupled neurons at the levels of gene expression and physiological activity during development and in the adult animal.

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Innexin expression in electrically coupled motor circuits

Note: Research in this publication was not performed at Janelia.

Abstract

Janelia Authors