Lineage-guided Notch-dependent gliogenesis by multi-potent progenitors.

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Development (Cambridge, England). 2018 May 15;. doi: 10.1242/dev.160127

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Ren Q, Awasaki T, Wang Y, Huang Y, Lee T

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Abstract

Macroglial cells in the central nervous system exhibit regional specialization and carry out region-specific functions. Diverse glial cells arise from specific progenitors in specific spatiotemporal patterns. This raises an interesting possibility that there exist glial precursors with distinct developmental fates, which govern region-specific gliogenesis. Here we mapped the glial progeny produced by the type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via intermediate neural progenitors (INPs). Distinct type II neuroblasts produce different characteristic sets of glia. A single INP can make both astrocyte-like and ensheathing glia, which co-occupy a relatively restrictive subdomain. Blocking apoptosis uncovers further lineage distinctions in the specification, proliferation, and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting gliogenesis.

PMID: 29764857 [PubMed - indexed for MEDLINE]

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Lineage-guided Notch-dependent gliogenesis by multi-potent progenitors.

Abstract

PMID: 29764857 [PubMed - indexed for MEDLINE]

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