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Malaria enhances expression of CC chemokine receptor 5 on placental macrophages.

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The Journal of Infectious Diseases. 2001 Mar 15;183(6):967-72. doi: 10.1086/319248
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Malaria enhances expression of CC chemokine receptor 5 on placental macrophages.
Tkachuk AN, Moormann AM, Poore JA, Rochford RA, Chensue SW, Mwapasa V, Meshnick SR
Note: Research in this publication was not performed at Janelia.
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Abstract

Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5(+) maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells.

PMID: 11237815 [PubMed - indexed for MEDLINE]

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