MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy.

Our Research / Publications

janelia7_blocks-janelia7_biblio_header | block

Nature Methods. 2007 Feb;4(2):161-8. doi: 10.1038/nmeth987

View Article on

Matsui T, Koyano KW, Koyama M, Nakahara K, Takeda M, Ohashi Y, Naya Y, Miyashita Y

Note: Research in this publication was not performed at Janelia.

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

The localization of microelectrode recording sites in the layers of primate cerebral cortex permits the analysis of relationships between recorded neuronal activities and underlying anatomical connections. We present a magnetic resonance imaging method for precise in vivo localization of cortical recording sites. In this method, the susceptibility-induced effect thickens the appearance of the microelectrode and enhances the detectability of the microelectrode tip, which usually occupies less than a few percent of the volume of an image voxel. In a phantom study, the optimized susceptibility-induced effect allowed tip detection with single-voxel accuracy (in-plane resolution, 50 mum). We applied this method to recording microelectrodes inserted into the brains of macaque monkeys, and localized the microelectrode tip at an in-plane resolution of 150 mum within the cortex of 2-3 mm in thickness. Subsequent histological analyses validated the single-voxel accuracy of the in vivo tip localization. This method opens up a way to investigate information flow during cognitive processes in the brain.

PMID: 17179936 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 17179936 [PubMed - indexed for MEDLINE]

Janelia Authors