Neurogeometry and potential synaptic connectivity.

Our Research / Publications

janelia7_blocks-janelia7_biblio_header | block

Trends in Neurosciences. 2005 Jul;28(7):387-94. doi: 10.1016/j.tins.2005.05.006

View Article on

Stepanyants A, Chklovskii DB

Note: Research in this publication was not performed at Janelia.

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

The advent of high-quality 3D reconstructions of neuronal arbors has revived the hope of inferring synaptic connectivity from the geometric shapes of axons and dendrites, or ’neurogeometry’. A quantitative description of connectivity must be built on a sound theoretical framework. Here, we review recent developments in neurogeometry that can provide such a framework. We base the geometric description of connectivity on the concept of a ’potential synapse’–the close apposition between axons and dendrites necessary to form an actual synapse. In addition to describing potential synaptic connectivity in neuronal circuits, neurogeometry provides insight into basic features of functional connectivity, such as specificity and plasticity.

PMID: 15935485 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

Neurogeometry and potential synaptic connectivity.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 15935485 [PubMed - indexed for MEDLINE]

Janelia Authors