Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum.

janelia7_blocks-janelia7_biblio_header | block

PLoS Biol. 2005 Jun;3(6):e175. doi: 10.1371/journal.pbio.0030175

Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. Spruston Lab

Cooper DC, Chung S, Spruston N

Note: Research in this publication was not performed at Janelia.

PDF

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Transitions between different behavioral states, such as sleep or wakefulness, quiescence or attentiveness, occur in part through transitions from action potential bursting to single spiking. Cortical activity, for example, is determined in large part by the spike output mode from the thalamus, which is controlled by the gating of low-voltage-activated calcium channels. In the subiculum--the major output of the hippocampus--transitions occur from bursting in the delta-frequency band to single spiking in the theta-frequency band. We show here that these transitions are influenced strongly by the inactivation kinetics of voltage-gated sodium channels. Prolonged inactivation of sodium channels is responsible for an activity-dependent switch from bursting to single spiking, constituting a novel mechanism through which network dynamics are controlled by ion channel gating.

PMID: 15857153 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 15857153 [PubMed - indexed for MEDLINE]

Janelia Authors