Phenotype clustering of breast epithelial cells in confocal images based on nuclear protein distribution analysis.

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BMC Cell Biology. 2007 Jul 10;8 (Suppl 1):S3. doi: 10.1007/s12021-010-9090-x
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Phenotype clustering of breast epithelial cells in confocal images based on nuclear protein distribution analysis.
Long F, Peng H, Sudar D, Lelièvre SA, Knowles DW
Note: Research in this publication was not performed at Janelia.
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Abstract

The distribution of chromatin-associated proteins plays a key role in directing nuclear function. Previously, we developed an image-based method to quantify the nuclear distributions of proteins and showed that these distributions depended on the phenotype of human mammary epithelial cells. Here we describe a method that creates a hierarchical tree of the given cell phenotypes and calculates the statistical significance between them, based on the clustering analysis of nuclear protein distributions.

PMID: 17634093 [PubMed - indexed for MEDLINE]

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Janelia Authors

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