Reconciling the deep homology of neuromodulation with the evolution of behavior.

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Current Opinion in Neurobiology. 2014 May 27;29C:39-47. doi: 10.1016/j.conb.2014.05.002

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Reconciling the deep homology of neuromodulation with the evolution of behavior. Dickson Lab

Katz PS, Lillvis JL

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Abstract

The evolution of behavior seems inconsistent with the deep homology of neuromodulatory signaling. G protein coupled receptors (GPCRs) evolved slowly from a common ancestor through a process involving gene duplication, neofunctionalization, and loss. Neuropeptides co-evolved with their receptors and exhibit many conserved functions. Furthermore, brain areas are highly conserved with suggestions of deep anatomical homology between arthropods and vertebrates. Yet, behavior evolved more rapidly; even members of the same genus or species can differ in heritable behavior. The solution to the paradox involves changes in the compartmentalization, or subfunctionalization, of neuromodulation; neurons shift their expression of GPCRs and the content of monoamines and neuropeptides. Furthermore, parallel evolution of neuromodulatory signaling systems suggests a route for repeated evolution of similar behaviors.

PMID: 24878891 [PubMed - indexed for MEDLINE]

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Reconciling the deep homology of neuromodulation with the evolution of behavior.

Abstract

PMID: 24878891 [PubMed - indexed for MEDLINE]

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