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Satb2 stations neurons along reflex arcs.

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Neuron. 2016 Aug 17;91(4):711-3. doi: 10.1016/j.neuron.2016.08.005
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Satb2 stations neurons along reflex arcs.
Hantman AW, Kaltschmidt JA
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Abstract

The nociceptive flexor withdrawal reflex has an august place in the history of neuroscience. In this issue of Neuron, Hilde et al. (2016) advance our understanding of this reflex by characterizing the molecular identity and circuit connectivity of component interneurons. They assess how a DNA-binding factor Satb2 controls cell position, molecular identity, pre-and postsynaptic targeting, and function of a population of inhibitory sensory relay interneurons that serve to integrate both proprioceptive and nociceptive afferent information.

The nociceptive flexor withdrawal reflex has an august place in the history of neuroscience. In this issue of Neuron, Hilde et al. (2016) advance our understanding of this reflex by characterizing the molecular identity and circuit connectivity of component interneurons. They assess how a DNA-binding factor Satb2 controls cell position, molecular identity, pre-and postsynaptic targeting, and function of a population of inhibitory sensory relay interneurons that serve to integrate both proprioceptive and nociceptive afferent information.

PMID: 27537478 [PubMed - indexed for MEDLINE]

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Janelia Authors

Adam Hantman
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