Sensing cellular biochemistry with fluorescent chemical–genetic hybrids

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Current Opinion in Chemical Biology. 2020 Jul;57:58–64. doi: 10.1016/j.cbpa.2020.04.005

Sensing cellular biochemistry with fluorescent chemical–genetic hybrids Tebo Lab

Gautier A, Tebo AG

Note: Research in this publication was not performed at Janelia.

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Abstract

Fluorescent biosensors are powerful tools for the detection of biochemical events inside cells with high spatiotemporal resolution. Biosensors based on fluorescent proteins often suffer from issues with photostability and brightness. On the other hand, hybrid, chemical–genetic systems present unique opportunities to combine the strengths of synthetic, organic chemistry with biological macromolecules to generate exquisitely tailored semisynthetic sensors.

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Sensing cellular biochemistry with fluorescent chemical–genetic hybrids

Note: Research in this publication was not performed at Janelia.

Abstract

Janelia Authors