The soft touch: low-affinity transcription factor binding sites in development and evolution.

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Current Topics in Developmental Biology. 2016 Jan 07;. doi: 10.1016/bs.ctdb.2015.11.018

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The soft touch: low-affinity transcription factor binding sites in development and evolution. Stern Lab

Crocker J, Ben Noon E, Stern DL

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Abstract

Transcription factor proteins regulate gene expression by binding to specific DNA regions. Most studies of transcription factor binding sites have focused on the highest affinity sites for each factor. There is abundant evidence, however, that binding sites with a range of affinities, including very low affinities, are critical to gene regulation. Here, we present the theoretical and experimental evidence for the importance of low-affinity sites in gene regulation and development. We also discuss the implications of the widespread use of low-affinity sites in eukaryotic genomes for robustness, precision, specificity, and evolution of gene regulation.

PMID: 26969995 [PubMed - indexed for MEDLINE]

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The soft touch: low-affinity transcription factor binding sites in development and evolution.

Abstract

PMID: 26969995 [PubMed - indexed for MEDLINE]

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