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janelia7_blocks-janelia7_biblio_header | block
Genes & Development. 2008 Sep 1;22(17):2353-8. doi: 10.1073/pnas.1100640108
TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription. Tjian Lab

Hsu J, Juven-Gershon T, Marr MT, Wright KJ, Tjian R, Kadonaga JT
Note: Research in this publication was not performed at Janelia.
janelia7_blocks-janelia7_biblio_abstract | block
Abstract
The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this circuit, TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription. This regulatory circuit is likely to be one means by which biological networks can transmit transcriptional signals, such as those from DPE-specific and TATA-specific enhancers, via distinct pathways.
PMID: 18703680 [PubMed - indexed for MEDLINE]
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Janelia Authors
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