Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila.

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Neural Development. 2009 Nov 2;4:39. doi: 10.1186/1749-8104-4-39
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Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila. Riddiford LabTruman Lab
Zhou B, Williams DW, Altman J, Riddiford LM, Truman JW
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Abstract

During the development of the central nervous system (CNS) of Drosophila, neuronal stem cells, the neuroblasts (NBs), first generate a set of highly diverse neurons, the primary neurons that mature to control larval behavior, and then more homogeneous sets of neurons that show delayed maturation and are primarily used in the adult. These latter, ’secondary’ neurons show a complex pattern of expression of broad, which encodes a transcription factor usually associated with metamorphosis, where it acts as a key regulator in the transitions from larva and pupa.

PMID: 19883497 [PubMed - indexed for MEDLINE]

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Janelia Authors

Jim Truman
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