The functional organization of descending sensory-motor pathways in Drosophila.

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eLife. 2018 Jun 26;:e34272. doi: 10.7554/eLife.34272

The functional organization of descending sensory-motor pathways in Drosophila. Card LabFly Descending InterneuronFlyLight

Namiki S, Dickinson MH, Wong AM, Korff W, Card GM

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Abstract

In most animals, the brain controls the body via a set of descending neurons (DNs) that traverse the neck. DN activity activates, maintains or modulates locomotion and other behaviors. Individual DNs have been well-studied in species from insects to primates, but little is known about overall connectivity patterns across the DN population. We systematically investigated DN anatomy in Drosophila melanogaster and created over 100 transgenic lines targeting individual cell types. We identified roughly half of all Drosophila DNs and comprehensively map connectivity between sensory and motor neuropils in the brain and nerve cord, respectively. We find the nerve cord is a layered system of neuropils reflecting the fly's capability for two largely independent means of locomotion -- walking and flight -- using distinct sets of appendages. Our results reveal the basic functional map of descending pathways in flies and provide tools for systematic interrogation of neural circuits.

PMID: 29943730 [PubMed - indexed for MEDLINE]

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First published in bioRxiv: http://dx.doi.org/10.1101/231696 on December 11, 2017.

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The functional organization of descending sensory-motor pathways in Drosophila.

Abstract

PMID: 29943730 [PubMed - indexed for MEDLINE]

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