The organization and development of cortical interneuron presynaptic circuits are area specific.

Our Research / Publications

janelia7_blocks-janelia7_biblio_header | block

Cell Reports. 2021 Nov 09;37(6):109993. doi: 10.1016/j.celrep.2021.109993

View Article on

Pouchelon G, Dwivedi D, Bollmann Y, Agba CK, Xu Q, Mirow AM, Kim S, Qiu Y, Sevier E, Ritola KD, Cossart R, Fishell G

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory and cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant and are thought to form canonical circuits regardless of which area they are embedded in. Here, we investigate whether this is achieved through selective and systematic variations in their afferent connectivity during development. To this end, we examined the development of their inputs within distinct cortical areas. We find that interneuron afferents show little evidence of being globally stereotyped. Rather, each subtype displays characteristic regional connectivity and distinct developmental dynamics by which this connectivity is achieved. Moreover, afferents dynamically regulated during development are disrupted by early sensory deprivation and in a model of fragile X syndrome. These data provide a comprehensive map of interneuron afferents across cortical areas and reveal the logic by which these circuits are established during development.

PMID: 34758329 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

The organization and development of cortical interneuron presynaptic circuits are area specific.

Abstract

PMID: 34758329 [PubMed - indexed for MEDLINE]

Janelia Authors