Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons.

Our Research / Publications

janelia7_blocks-janelia7_biblio_header | block

Proc Natl Acad Sci U S A. 2019 Jul;116(32):16068-16073. doi: 10.1073/pnas.1905832116

View Article on

Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons. Li Lab

Xie Q, Wu B, Li J, Xu C, Li H, Luginbuhl DJ, Wang X, Ward A, Luo L

Note: Research in this publication was not performed at Janelia.

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Our understanding of the mechanisms of neural circuit assembly is far from complete. Identification of wiring molecules with novel mechanisms of action will provide insights into how complex and heterogeneous neural circuits assemble during development. In the olfactory system, 50 classes of olfactory receptor neurons (ORNs) make precise synaptic connections with 50 classes of partner projection neurons (PNs). Here, we performed an RNA interference screen for cell surface molecules and identified the leucine-rich repeat-containing transmembrane protein known as Fish-lips (Fili) as a novel wiring molecule in the assembly of the olfactory circuit. Fili contributes to the precise axon and dendrite targeting of a small subset of ORN and PN classes, respectively. Cell-type-specific expression and genetic analyses suggest that Fili sends a transsynaptic repulsive signal to neurites of nonpartner classes that prevents their targeting to inappropriate glomeruli in the antennal lobe.

Main Menu (Mobile)- Block

Main Menu - Block

Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 31341080 [PubMed - indexed for MEDLINE]

Janelia Authors