Two-photon imaging with silicon photomultipliers.

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Optics Express. 2019 Nov 25;27(24):35830-35841. doi: 10.1364/OE.27.035830

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Two-photon imaging with silicon photomultipliers. Turner LabPodgorski Lab

Modi MN, Daie K, Turner GC, Podgorski K

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Abstract

We compared performance of recently developed silicon photomultipliers (SiPMs) to GaAsP photomultiplier tubes (PMTs) for two-photon imaging of neural activity. Despite higher dark counts, SiPMs match or exceed the signal-to-noise ratio of PMTs at photon rates encountered in typical calcium imaging experiments due to their low pulse height variability. At higher photon rates encountered during high-speed voltage imaging, SiPMs substantially outperform PMTs.