Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers.

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Developmental Dynamics: An Official Publication of the American Association of Anatomists. 2012 Jan;241:169-89. doi: 10.1002/dvdy.22728
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Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers.
Brody T, Yavatkar AS, Kuzin A, Kundu M, Tyson LJ, Ross J, Lin T, Lee C, Awasaki T, Lee T, Odenwald WF
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Abstract

Phylogenetic footprinting has revealed that cis-regulatory enhancers consist of conserved DNA sequence clusters (CSCs). Currently, there is no systematic approach for enhancer discovery and analysis that takes full-advantage of the sequence information within enhancer CSCs.

PMID: 22174086 [PubMed - indexed for MEDLINE]

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