Molecular Mechanisms in the Synapse: Experiments and Modeling
The mechanisms that control synaptic transmission in the central nervous system operate over a wide range of time windows. Transmitter release and recovery occur over a few milliseconds to several seconds after a stimulus. The postsynaptic voltage response can last a few hundred milliseconds after the stimulus but the biochemical adjustments to synaptic strength that underlie neural plasticity often continue over several seconds to hours and days. To learn how these events are orchestrated and regulated, the complex molecular machinery responsible for transmission and plasticity has been probed by anatomists, biochemists, electrophysiologists and computational modelers. This meeting brings together individuals from these diverse disciplines with the goal of exploring how experimental and computational approaches can be better integrated to produce a deeper understanding of synaptic mechanisms.
Organizers
Reinhard Jahn, Max Planck Institute for Biophysical Chemistry
Mary Kennedy, California Institute of Technology
Terrence Sejnowski, HHMI/Salk Institute for Biological Studies
Invited Participants
Tom Bartol, Salk Institute for Biological Studies
Patricia Bassereau, CNRS, Institut Curie
Upinder Bhalla, National Centre for Biological Sciences
Avrama Blackwell, George Mason University
Nils Brose, Max Planck Institute for Experimental Medicine
Axel Brunger, HHMI/Stanford University
Lu Chen, Stanford University
Daniel Choquet, University of Bordeaux
Martha Constantine-Paton, Massachusetts Institute of Technology
Pietro De Camilli, HHMI/Yale University
David DiGregorio, Institut Pasteur
Dennis Glanzman, National Institute of Mental Health, NIH
Kristen Harris, University of Texas at Austin
Johannes Hell, University of California, Davis
Peter Jonas, Institute of Science and Technology, Austria
Eric Jörgensen, HHMI/University of Utah
Nicolas Le Novère, University of Cambridge
Yuan Liu, National Institute of Neurological Disorders and Stroke, NIH
Robert Malenka, Stanford University School of Medicine
Suhita Nadkarni, Indian Institute of Science Education and Research (IISER)
Erwin Neher, Max Planck Institute for Biophysical Chemistry
Tom Reese, National Institute of Neurological Disorders and Stroke, NIH
Christian Rosenmund, Charité Universitaetsmedizin Berlin
Bernardo Sabatini, HHMI/Harvard University
Todd Sacktor, SUNY Downstate Medical Center
Kang Shen, HHMI/Stanford University
Susumu Tomita, Yale University
Neal Waxham, University of Texas Health Science Center at Houston
