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Support Teams / Cryo-Electron Microscopy
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Representative Publications with data obtained at the facility

 

  1. FOXP3 recognizes microsatellites and bridges DNA through multimerization.
     Wenxiang Zhang, Fangwei Leng, Xi Wang, Ricardo N. Ramirez, Jinseok Park, Christophe Benoist & Sun Hur.
    Nature. 2023 November 29; doi.org/10.1038/s41586-023-06793-z
  2. The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis.
    Maria E. Falzone and Roderick MacKinnon.
    PNAS. 2023 November 22; 120 (48) e2315011120; doi.org/10.1073/pnas.2315011120
  3. The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization. Wenshuai Wang, Benjamin Götte, Rong Guo & Anna Marie Pyle.
    Nature Communications. 2023 November 11; 14, Article number: 7308 (2023); doi.org/10.1038/s41467-023-42982-0
  4. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.
     Zhen Chen, Momoko Shiozaki, Kelsey M. Haas, ..., Robyn M. Kaake, Ronald D. Vale, David A. Agard.
    Cell. 2023 November 9; doi.org/10.1016/j.cell.2023.09.017
  5. Structural basis for inactivation of PRC2 by G-quadruplex RNA.
     Jiarui Song, Anne R. Gooding, Wayne O. Hemphill, Brittney D. Love, Anne Robertson, Liqi Yao, Leonard I. Zon, Trista E. North, Vignesh Kasinath, and Thomas R. Cech.
    Science. 2023 September 21; Vol 381, Issue 6664, pp. 1331-1337; DOI: 10.1126/science.adh0059
  6. Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology.
    Chang Sun, Hongtao Zhu, Sarah Clark & Eric Gouaux.
    Nature volume 622, pages195–201 (2023). 2023 September 20; doi.org/10.1038/s41586-023-06556-w
  7. Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
    Naotaka Tsutsumi, Zahra Masoumi, Sophie C. James, ..., Jacob Piehler, Ian S. Hitchcock, K. Christopher Garcia.
    Cell. 2023 September 14; 186, 1–15; doi.org/10.1016/j.cell.2023.07.037
  8. Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen.
    Katharine M. Wright, Sarah R. DiNapoli, Michelle S. Miller, P. Aitana Azurmendi, Xiaowei Zhao, Zhiheng Yu, Mayukh Chakrabarti, WuXian Shi, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou & Sandra B. Gabelli.
    Nature Communications. 2023 August 21; 14, Article number: 5063 (2023); doi.org/10.1038/s41467-023-40821-w
  9. Structure of C. elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
    Sarah Clark, Hanbin Jeong, Rich Posert, April Goehring, Eric Gouaux. bioRxiv. 2023 August 17; doi.org/10.1101/2023.08.16.553618
  10. Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
    Shengjie Feng, Cristina Puchades, Juyeon Ko, Hao Wu, Yifei Chen, Eric E. Figueroa, Shuo Gu, Tina W. Han, Brandon Ho, Tong Cheng, Junrui Li, Brian Shoichet, Yuh Nung Jan, Yifan Cheng & Lily Yeh Jan.
    Nature Communications. 2023 August 12; Nature Communications 14; Article number: 4874 (2023); doi.org/10.1038/s41467-023-40410-x
  11. Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
    Jiyuan Zhang, Weizhong Zeng, Yan Han, Wan-Ru Lee, Jen Liou, Youxing Jiang.
    Molecular Cell. 2023 July 20; Volume 83; Issue 14 (2023); pgs 2524-2539.e7; doi.org/10.1016/j.molcel.2023.06.004.
  12. Structural insights into intron catalysis and dynamics during splicing.
    Ling Xu, Tianshuo Liu, Kevin Chung & Anna Marie Pyle.
    Nature. 2023 July 17; doi.org/10.1038/s41586-023-06746-6
  13. Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants.
    Dongxue Yang, Zhiyu Zhao, Emad Tajkhorshid, and Eric Gouaux.
    PNAS. 2023 July 12; 120 (29) e2304602120; doi.org/10.1073/pnas.2304602120
  14. Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography.
    Mohammed Kaplan, Yi-Wei Chang, Catherine M. Oikonomou, William J. Nicolas, Andrew I. Jewett, Stefan Kreida, Przemysław Dutka, Lee A. Rettberg, Stefano Maggi & Grant J. Jensen.
    Nature Microbiology 8, pages1267–1279 (2023). 2023 June 22; doi.org/10.1038/s41564-023-01401-2
  15. The principles of peptide selection by the transporter associated with antigen processing [preprint].
    James Lee, Michael L. Oldham, Victor Manon, Jue Chen.
    bioRxiv. 2023 June 17; doi.org/10.1101/2023.06.16.545308
  16. Quantification of gallium cryo-FIB milling damage in biological lamellae.
    Bronwyn A. Lucas and Nikolaus Grigorieff.
    PNAS. 2023 May 22; 120 (23) e2301852120; doi.org/10.1073/pnas.2301852120
  17. The membrane electric field regulates the PIP2-binding site to gate the KCNQ1 channel.
    Venkata Shiva Mandala and Roderick MacKinnon.
    PNAS. 2023 May 16; 120 (21) e2301985120; doi.org/10.1073/pnas.2301985120
  18. Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface.
     Maria E. Falzone and Roderick MacKinnon.
    PNAS. 2023 May 12;120 (20) e2301121120; doi.org/10.1073/pnas.2301121120
  19. Lipid flipping in the omega-3 fatty-acid transporter.
    Chi Nguyen, Hsiang-Ting Lei, Louis Tung Faat Lai, Marc J. Gallenito, Xuelang Mu, Doreen Matthies & Tamir Gonen.
    Nature Communications 14, 2571 (2023). 2023 May 8; doi.org/10.1038/s41467-023-37702-7
  20. Membrane protein isolation and structure determination in cell-derived membrane vesicles.
    Xiao Tao,     Chen Zhao, and Roderick MacKinnon.
    PNAS. 2023 April 25; 120 (18) e2302325120; doi.org/10.1073/pnas.2302325120
  21. The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins.
    Alexandria N Miller, Patrick R Houlihan, Ella Matamala, Deny Cabezas-Bratesco, Gi Young Lee, Ben Cristofori-Armstrong, Tanya L Dilan, Silvia Sanchez-Martinez, Doreen Matthies, David E Clapham.
    eLife. 2023 January 25; 12:e84477; doi.org/10.7554/eLife.84477
  22. Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.
    J. Andrew N. Alexander, Liam J. Worrall, Jinhong Hu, Marija Vuckovic, Nidhi Satishkumar, Raymond Poon, Solmaz Sobhanifar, Federico I. Rosell, Joshua Jenkins, Daniel Chiang, Wesley A. Mosimann, Henry F. Chambers, Mark Paetzel, Som S. Chatterjee & Natalie C. J. Strynadka.
    Nature. 2023 January 4; Nature volume 613, pages375–382 (2023); doi.org/10.1038/s41586-022-05583-3
  23. In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes.
    Zhen Chen, Garrett A. Greenan, Momoko Shiozaki, Yanxin Liu, Will M. Skinner, Xiaowei Zhao, Shumei Zhao, Rui Yan, Zhiheng Yu, Polina V. Lishko, David A. Agard & Ronald D. Vale.
    Nature Structural & Molecular Biology. 2023 January 2; 30, pages360–369 (2023).     doi.org/10.1038/s41594-022-00861-0
  24. Multifunctional Protein A Is the Only Viral Protein Required for Nodavirus RNA Replication Crown Formation.
    Johan A. den Boon, Hong Zhan, Nuruddin Unchwaniwala, Mark Horswil, Kailey Slavik, Janice Pennington, Amanda Navine, and Paul Ahlquist.
    Viruses. 2022 Dec 3; 14(12), 2711; doi.org/10.3390/v14122711
  25. Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.
    Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E. Wilkinson, Soumya Kannan, F. Esra Demircioglu, Rui Yan, Momoko Shiozaki, Zhiheng Yu, Kira S. Makarova, Eugene V. Koonin, Rhiannon K. Macrae & Feng Zhang.
    Nature. 2022 October 12; 610, pages575–581. doi.org/10.1038/s41586-022-05324-6
  26. Structures of the TMC-1 complex illuminate mechanosensory transduction.
     Hanbin Jeong, Sarah Clark, April Goehring, Sepehr Dehghani-Ghahnaviyeh, Ali Rasouli, Emad Tajkhorshid & Eric Gouaux.
    Nature 610, 796-803 (2022). 2022 October 12; doi.org/10.1038/s41586-022-05314-8.
  27. De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography.
     Zhen Chen, Momoko Shiozaki, Kelsey M. Haas, Shumei Zhao, Caiying Guo, Benjamin J. Polacco, Zhiheng Yu, Nevan J. Krogan, Robyn M. Kaake, Ronald D. Vale, David A. Agard.
    bioRxiv. 2022 September 29; doi.org/10.1101/2022.09.28.510016
  28. Organizing structural principles of the IL-17 ligand–receptor axis.
    Steven C. Wilson, Nathanael A. Caveney, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M. Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler & K. Christopher Garcia.
    Nature. 2022 July 21; Nature volume 609, pages622–629 (2022); doi.org/10.1038/s41586-022-05116-y
  29. In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts.
    Shujun Cai, Yumei Wu, Adres Guillen-Samander, and Piertro De Camilli.
    PNAS. 2022 July 13; 119 (29) e2203769119; doi.org/10.1073/pnas.2203769119
  30. Allosteric interactions prime androgen receptor dimerization and activation.
    Elizabeth V.Wasmuth, Arnaud Vanden Broeck, Justin R. LaClair,..., Susan T. Weintraub, Sebastian Klinge, Charles L.Sawyers.
    Molecular Cell. 2022 June 2; 82,2021–2031; doi.org/10.1016/j.molcel.2022.03.035
  31. Structure of the IL-27 quaternary receptor signaling complex.
    Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi, K Christopher Garcia.
    eLife. 2022 May 17; 11:e78463; doi.org/10.7554/eLife.78463
  32. Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.
    Lan Wang, Hannah Toutkoushian, Vladislav Belyy, Claire Y Kokontis, Peter Walter.
    eLife. 2022 May 12; 11:e73941; doi.org/10.7554/eLife.73941
  33. Structural basis of NPR1 in activating plant immunity.
    Shivesh Kumar, Raul Zavaliev, Qinglin Wu, Ye Zhou, Jie Cheng, Lucas Dillard, Jordan Powers, John Withers, Jinshi Zhao, Ziqiang Guan, Mario J. Borgnia, Alberto Bartesaghi, Xinnian Dong & Pei Zhou.
    Nature. 2022 May 11; 605, pages561–566; doi.org/10.1038/s41586-022-04699-w
  34. Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
    Nadine M. Shaban, Rui Yan, Ke Shi, Sofia N. Maraes, Reuben S. Harris.
    Science Advances. 2022 April 27; Vol 8, Issue 17; DOI: 10.1126/sciadv.abm2827
  35. CENP-N promotes the compaction of centromeric chromatin.
    Keda Zhou, Magdalena Gebala, Dustin Woods, Kousik Sundararajan, Garrett Edwards, Dan Krzizike, Jeff Wereszczynski, Aaron F. Straight & Karolin Luger.
    Nature Structural & Molecular Biology. 2022 April 14; 29, pages403–413 (2022); doi.org/10.1038/s41594-022-00758-y
  36. Structure of the human ATM kinase and mechanism of Nbs1 binding.
     Christopher Warren, Nikola P. Pavletich.
    eLife. 2022 January 25; doi.org/10.7554/eLife.74218
  37. Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography.
    Johannes Elferich, Sarah Clark, Jingpeng Ge, April Goehring, Aya Matsui, Eric Gouaux.
    eLife. 2021 December 29; doi.org/10.7554/eLife.74512
  38. Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2.
    Akihito Fukudome, Jasleen Singh, Vibhor Mishra, and Craig S. Pikaard.
    PNAS. 2021 Decemeber 13; 118 (51) e2115899118; doi.org/10.1073/pnas.2115899118
  39. A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
    Yongjian Huang, Jana Ognjenović, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan.
    eLife. 2021 November 30; doi.org/10.7554/eLife.73218
  40. SMARCAD1 is an ATP-dependent histone octamer exchange factor with de novo nucleosome assembly activity.
     Jonathan Markert, Keda Zhou, and Karolin Luger.
    Science Advances. 2021 October 15; Vol 7, Issue 42; DOI: 10.1126/sciadv.abk2380
  41. The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease.
     Aurelie de Rus Jacquet, Jenna L Tancredi, Andrew L Lemire, Michael C DeSantis, Wei-Ping Li, Erin K O'Shea.
    eLife. 2021 September 30; doi.org/10.7554/eLife.73062
  42. Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.
     Qin Cao, David R. Boyer, Michael R. Sawaya, Romany Abskharon, Lorena Saelices, Binh A. Nguyen, Jiahui Lu, Kevin A. Murray, Fouad Kandeel & David S. Eisenberg.
    Nature Structural & Molecular Biology. 2021 September 9; Nat Struct & Mol Bio volume 28, pages724–730 (2021); doi.org/10.1038/s41594-021-00646-x
  43. Molecular basis of cholesterol efflux via ABCG subfamily transporters
    .     Yingyuan Sun, Jin Wang, Tao Long, Xiaochun Li, (Contributed by Helen Hobbs).
    PNAS. 2021 August 17; 118 (34) e2110483118; doi.org/10.1073/pnas.2110483118
  44. TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase.
    Jing Xue, Yan Han, Hamid Baniasadi Weizhong Zeng, Jimin Pei, Nick V Grishin, Junmei Wang, Benjamin P Tu, Youxing Jiang.
    eLife. 2021 August 10; doi.org/10.7554/eLife.71220
  45. Virus-encoded histone doublets are essential and form nucleosome-like structures.
     Yang Liu, Hugo Bisio, Chelsea Marie Toner,...,Garrett Edwards, Chantal Abergel, Karolin Luger.
    Cell. 2021 August 5; 184,4237–4250; doi.org/10.1016/j.cell.2021.06.032
  46. Structural mechanisms of gating and selectivity of human rod CNGA1 channel,
    Jing Xue, Yan Han, Weizhong Zeng, Yan Wang, Youxing Jiang.
    Neuron. 2021 April 21; Volume 109, Issue 8, 2021, pages 1302-1313.e4; doi.org/10.1016/j.neuron.2021.02.007.
  47. Structure and function of the chromatin remodeler SMARCAD1 with its nucleosome substrate [preprint].
    Jonathan Markert, Keda Zhou, Karolin Luger.
    bioRxiv. 2021 April 14; doi.org/10.1101/2021.04.14.439859
  48. Structure of the p53/RNA polymerase II assembly.
    Shu-Hao Liou, Sameer K. Singh, Robert H. Singer, Robert A. Coleman & Wei-Li Liu.
    Communications Biology. 2021 March 25; 4, Article number: 397 (2021); doi.org/10.1038/s42003-021-01934-4
  49. Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
    Robert Saxton, Naotaka Tsutsumi, Leon L. Su, Gita C. Abhiraman, Kritika Mohan, Lukas T. Henneberg, Nanda G. Aduri, Cornelius Gati, and K Christopher Garcia.
    Science. 2021 March 19; Vol 371, Issue 6535; DOI: 10.1126/science.abc8433
  50. Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport.
    Biao Qui, Doreen Matthies, Eva Fortea, Zhiheng Yu, Olga Boudker.
    Science Advances. 2021 March 3; Vol 7, Issue 10; DOI: 10.1126/sciadv.abf5814
  51. Mechanism of gating and partial agonist action in the glycine receptor.
     Jie Yu, Hongtao Zhu, Remigijus Lape,..., Wei Lu¨, Lucia Sivilotti, Eric Gouaux.
    Cell. 2021 February 18; 184,957–968; https://doi.org/10.1016/j.cell.2021.01.026.
  52. Pre-termination Transcription Complex: Structure and Function.
    Zhitai Hao, Vitaly Epshtein, Kelly H. Kim,..., Alexander Mironov, Thomas Walz, Evgeny Nudler.
    Molecular Cell. 2021 January 21; 81,281–292; doi.org/10.1016/j.molcel.2020.11.013
  53. The structural basis of Rubisco phase separation in the pyrenoid.
    Shan He, Hui-Ting Chou, Doreen Matthies, Tobias Wunder, Moritz T. Meyer, Nicky Atkinson, Antonio Martinez-Sanchez, Philip D. Jeffrey, Sarah A. Port, Weronika Patena, Guanhua He, Vivian K. Chen, Frederick M. Hughson, Alistair J. McCormick, Oliver Mueller-Cajar, Benjamin D. Engel, Zhiheng Yu & Martin C. Jonikas.
    Nature Plants. 2020 November 23; Nature Plants volume 6, pages1480–1490 (2020); doi.org/10.1038/s41477-020-00811-y
  54. Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
    Guillaume Gaullier, Genevieve Roberts, Uma M. Muthurajan, Samuel Bowerman, Johannes Rudolph, Jyothi Mahadevan, Asmita Jha, Purushka S. Rae, Karolin Luger.
    PLOS ONE. 2020 November 3; doi.org/10.1371/journal.pone.0240932
  55. Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
    Naotaka Tsutsumi, Somnath Mukherjeem Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, K Christopher Garcia.
    eLife. 2020 August 7; eLife 9:e58464; doi.org/10.7554/eLife.58464
  56. Structure of human GABAB receptor in an inactive state.
    Jinseo Park, Ziao Fu, Aurel Frangaj, Jonathan Liu, Lidia Mosyak, Tong Shen, Vesna N. Slavkovich, Kimberly M. Ray, Jaume Taura, Baohua Cao, Yong Geng, Hao Zuo, Yongjun Kou, Robert Grassucci, Shaoxia Chen, Zheng Liu, Xin Lin, Justin P. Williams, William J. Rice, Edward T. Eng, Rick K. Huang, Rajesh K. Soni, Brian Kloss, Zhiheng Yu, Jonathan A. Javitch, Wayne A. Hendrickson, Paul A. Slesinger, Matthias Quick, Joseph Graziano, Hongtao Yu, Oliver Fiehn, Oliver B. Clarke, Joachim Frank & Qing R. Fan.
    Nature. 2020 June 24; 584, pages304–309 (2020); doi.org/10.1038/s41586-020-2452-0
  57. Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication.
    Hong Zhan, Janice Pennington, Paul Ahlquist.
    PNAS. 2020 June 9; 117 (31) 18680-18691; doi.org/10.1073/pnas.2006165117
  58. The structure of human CST reveals a decameric assembly bound to telomeric DNA.
    Ci Ji Lim, Alexandra T. Barbour, Arthur J. Zaug, Allison E. McKay, Deborah S. Wuttke, Thomas R. Cech. Science. 2020 June 5; Vol 368, Issue 6495, pp. 1081-1085. DOI: 10.1126/science.aaz9649
  59. LetB Structure Reveals a Tunnel for Lipid Transport across the Bacterial Envelope.
    Georgia L. Isom, Nicolas Coudray, Mark R. MacRae, Collin T. McManus, Damian C. Ekiert, Gira Bhabha.
    Cell. 2020 April 30; 181,653–664; doi.org/10.1016/j.cell.2020.03.030
  60. Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex.
    Xudong Wu, Marc Siggel, Sergey Ovchinnikov, Wei Mi, Vladimir Svetlov, Evgeny Nudler, Maofu Liao, Gerhard Hummer, and Tom A. Rapoport.
    Science. 2020 April 24; Vol 368, Issue 6489; DOI: 10.1126/science.aaz2449.
  61. Label-free single-instance protein detection in vitrified cells.
    J. Peter Rickgauer, Heejun Choi, Jennifer Lippincott-Schwartz, Winfried Denk.
    bioRxiv. 2020 April 24;     doi.org/10.1101/2020.04.22.053868
  62. Molecular structures of the human Slo1 K+ channel in complex with β4.
    Xiao Tao, Roderick MacKinnon.
    eLife. 2019 December 9; doi.org/10.7554/eLife.51409
  63. Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex.
    Anthony H. Nguyen, Alex R. B. Thomsen, Thomas J. Cahill III, Rick Huang, Li-Yin Huang, Tara Marcink, Oliver B. Clarke, Søren Heissel, Ali Masoudi, Danya Ben-Hail, Fadi Samaan, Venkata P. Dandey, Yong Zi Tan, Chuan Hong, Jacob P. Mahoney, Sarah Triest, John Little IV, Xin Chen, Roger Sunahara, Jan Steyaert, Henrik Molina, Zhiheng Yu, Amedee des Georges & Robert J. Lefkowitz.
    Nature Structural & Molecular Biology. 2019 November 18; volume 26, pages1123–1131; doi.org/10.1038/s41594-019-0330-y
  64. Structure-based inhibitors of amyloid beta core suggest a common interface with tau.
    Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, David S Eisenberg.
    eLife. 2019 October 15; 8:e46924; doi.org/10.7554/eLife.46924.
  65. Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response.
    Aditya A. Anand, Peter Walter.
    The FEBS Journal. 2019 September 24; 287(2), 239-245; doi.org/10.1111/febs.15073
  66. Cryo-EM Studies ofT MEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
     Shengjie Feng, Shangyu Dang, Tina Wei Han,...,Yuh Nung Jan, Lily Yeh Jan,Yifan Cheng.
    Cell Reports. 2019 July 9; 28,567–579; doi.org/10.1016/j.celrep.2019.06.023
  67. Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain.
    Stefan Niekamp, Nicolas Coudray, Nan Zhang, Ronald D. Vale, Gira Bhadha.
    The EMBO Journal. 2019 May 31; 38:e101414; doi.org/10.15252/embj.2018101414
  68. Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.

Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ.

Nat Struct Mol Biol. 2019 Dec;26(12):1123-1131. doi: 10.1038/s41594-019-0330-y.

  1. Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.

Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM.

Cell. 2019 Nov 27;179(6):1319-1329.e8. doi: 10.1016/j.cell.2019.10.036.

  1. T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.

Hu J, Worrall LJ, Vuckovic M, Hong C, Deng W, Atkinson CE, Brett Finlay B, Yu Z, Strynadka NCJ.

Nat Microbiol. 2019 Nov;4(11):2010-2019. doi: 10.1038/s41564-019-0545-z.

  1. Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.

Majewski DD, Worrall LJ, Hong C, Atkinson CE, Vuckovic M, Watanabe N, Yu Z, Strynadka NCJ.

Nat Commun. 2019 Feb 7;10(1):626. doi: 10.1038/s41467-019-08477-7.

  1. Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF.

Nature. 2019 Jan;565(7737):118-121. doi: 10.1038/s41586-018-0779-6.

  1. In vivo structure of the Legionella type II secretion system by electron cryotomography.

Ghosal D, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ.

Nat Microbiol. 2019 Dec;4(12):2101-2108. doi: 10.1038/s41564-019-0603-6.

  1. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.

Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA.

Science. 2019 Aug 2;365(6452). pii: eaax1033. doi: 10.1126/science.aax1033.

  1. Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain.

Niekamp S, Coudray N, Zhang N, Vale RD, Bhabha G.

EMBO J. 2019 Jul 1;38(13):e101414. doi: 10.15252/embj.2018101414.

  1. Molecular architecture, polar targeting and biogenesis of the Legionella Dot/Icm T4SS.

Ghosal D, Jeong KC, Chang YW, Gyore J, Teng L, Gardner A, Vogel JP, Jensen GJ.

Nat Microbiol. 2019 Jul;4(7):1173-1182. doi: 10.1038/s41564-019-0427-4.

  1. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y.

Cell Rep. 2019 Jul 30;28(5):1385. doi: 10.1016/j.celrep.2019.07.052.

  1. Transposon molecular domestication and the evolution of the RAG recombinase.

Zhang Y, Cheng TC, Huang G, Lu Q, Surleac MD, Mandell JD, Pontarotti P, Petrescu AJ, Xu A, Xiong Y, Schatz DG.

Nature. 2019 May;569(7754):79-84. doi: 10.1038/s41586-019-1093-7.

  1. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.

Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A.

Science. 2019 May 3;364(6439):491-495. doi: 10.1126/science.aaw2922.

  1. Structural insight into TRPV5 channel function and modulation.

Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8869-8878. doi: 10.1073/pnas.1820323116.

  1. The complete structure of the human TFIIH core complex.

Greber BJ, Toso DB, Fang J, Nogales E.

Elife. 2019 Mar 12;8. pii: e44771. doi: 10.7554/eLife.44771.

  1. CryoEM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina.

Heymann JB, Vijayasarathy C, Huang RK, Dearborn AD, Sieving PA, Steven AC.

J Cell Biol. 2019 Mar 4;218(3):1027-1038. doi: 10.1083/jcb.201806148.

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Nature. 2019 Feb;566(7742):136-139. doi: 10.1038/s41586-018-0856-x.

  1. Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin.

Hu J, Worrall LJ, Hong C, Vuckovic M, Atkinson CE, Caveney N, Yu Z, Strynadka NCJ.

Nat Commun. 2018 Sep 21;9(1):3840. doi: 10.1038/s41467-018-06298-8.

  1. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

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  1. Cryo-EM structure of an essential Plasmodium vivax invasion complex.

Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH.

Nature. 2018. doi: 10.1038/s41586-018-0249-1.

  1. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.

Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV Jr, Walther TC.

J Cell Biol. 2018 Dec 3;217(12):4080-4091. doi: 10.1083/jcb.201809067.

 

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Ruhe ZC, Subramanian P, Song K, Nguyen JY, Stevens TA, Low DA, Jensen GJ, Hayes CS.

Cell. 2018 Nov 1;175(4):921-933.e14. doi: 10.1016/j.cell.2018.10.033.

  1. Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.

Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA.

Cell. 2018 Nov 15;175(5):1352-1364.e14. doi: 10.1016/j.cell.2018.10.026.

  1. Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.

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Cell. 2018 Nov 29;175(6):1520-1532.e15. doi: 10.1016/j.cell.2018.10.043.

  1. Partially Open HIV1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.

Wang H, Barnes CO, Yang Z, Nussenzweig MC, Bjorkman PJ.

Cell Host Microbe. 2018 Oct 10;24(4):579-592.e4. doi: 10.1016/j.chom.2018.09.003.

  1. Structural principles of SNARE complex recognition by the AAA+ protein NSF.

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Elife. 2018 Sep 10;7. pii: e38888. doi: 10.7554/eLife.38888.

  1. Structural basis for activation of voltage sensor domains in an ion channel TPC1.

Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9095-E9104. doi: 10.1073/pnas.1805651115.

  1. Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.

Ge J, Elferich J, Goehring A, Zhao H, Schuck P, Gouaux E.

Elife. 2018 Aug 2;7. pii: e38770. doi: 10.7554/eLife.38770.

  1. Cryo-EM structure of the polycystin 2-l1 ion channel.

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Elife. 2018 Jul 13;7. pii: e36931. doi: 10.7554/eLife.36931.

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Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5906-E5915. doi: 10.1073/pnas.1806315115.

  1. Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.

Jenni S, Harrison SC.

Science. 2018 May 4;360(6388):552-558. doi: 10.1126/science.aar6436.

  1. Structures of human PRC2 with its cofactors AEBP2 and JARID2.

Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E.

Science. 2018 Feb 23;359(6378):940-944. doi: 10.1126/science.aar5700.

  1. Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. 

Kim Y, Chen J. 

Science. 2018 Feb 23;359(6378):915-919.

  1. Integrative structure and functional anatomy of a nuclear pore complex.

Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP.

Nature. 2018 Mar 22;555(7697):475-482.

  1. Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.

Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H. 

Neuron. 2018 May 2;98(3):521-529.e3.

  1. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. 

Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. 

Science. 2018 Mar 30;359(6383).

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Close W, Neumann M, Schmidt A, Hora M, Annamalai K, Schmidt M, Reif B, Schmidt V, Grigorieff N, Fändrich M. 

Nat Commun. 2018 Feb 16;9(1):699.

  1. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. 

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL Jr, Cheng Y, Jan LY. 

Nature. 2017 Dec 21;552(7685):426-429. 

  1. Best Practices for Managing Large CryoEM Facilities

Bart Alewijnse, Alun W. Ashton, Melissa G. Chambers, Songye Chen, Anchi Cheng, Mark Ebrahim, Edward Eng, Wim J. H. Hagen, Abraham J. Koster, Claudia S. López, Natalya Lukoyanova, Joaquin Ortega, Ludovic Renault, Steve Reyntjens, William J. Rice, Giovanna Scapin, Raymond Schrijver, Alistair Siebert, Scott M. Stagg, Valerie Grum-Tokars, Elizabeth R. Wright, Shenping Wu, Zhiheng Yu, Z. Hong Zhou, Bridget Carragher, Clinton S. Potter

J Struct Biol. 2017 Sep; 199(3): 225–236. doi: 10.1016/j.jsb.2017.07.011

  1. Near-atomic resolution cryoelectron microscopy structure of the 30-fold homooligomeric SpoIIIAG channel essential to spore formation in Bacillus subtilis.

Zeytuni N, Hong C, Flanagan KA, Worrall LJ, Theiltges KA, Vuckovic M, Huang RK, Massoni SC, Camp AH, Yu Z, Strynadka NC.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7073-E7081. doi: 10.1073/pnas.1704310114.

  1. Structural basis of bacterial transcription activation. 

Liu B, Hong C, Huang RK, Yu Z, Steitz TA. 

Science. 2017;358(6365):947-951

  1. Decoding the centromeric nucleosome through CENP-N. 

Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K. 

Elife. 2017 Dec 27;6. pii: e33442

  1. Structure of RNA polymerase bound to ribosomal 30S subunit. 

Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA.

Elife. 2017 Oct 13;6. pii: e28560.

  1. The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.  

Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE.

Science. 2017;358(6365):888-893.

  1. Architectures of Lipid Transport Systems for the Bacterial Outer Membrane.

Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale RD. 

Cell. 2017;169(2):273-285.

  1. Ensemble cryo-EM elucidates the mechanism of translation fidelity.

Loveland AB, Demo G, Grigorieff N, Korostelev AA.

Nature. 2017;546(7656):113-117

  1. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.

Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M.

Nature. 2017 Aug 17;548(7667):352-355. doi: 10.1038/nature23314.

  1. Disabling Cas9 by an anti-CRISPR DNA mimic.

Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. 

Sci Adv. 2017;3(7):e1701620.

  1. Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.

Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI. 

Neuron. 2017; 94(3):569-580

  1. Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body. 

Worrall LJ, Hong C, Vuckovic M, Deng W, Bergeron JR, Majewski DD, Huang RK, Spreter T, Finlay BB, Yu Z, Strynadka NC.

Nature. 2016; 540:597-601. 

  1. Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones. 

Zhou CY, Stoddard CI, Johnston JB, Trnka MJ, Echeverria I, Palovcak E, Sali A, Burlingame AL, Cheng Y, Narlikar GJ. 

Cell Rep. 2017;19(10):2033-2044.

  1. Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies. 

Wang H, Gristick HB, Scharf L, West AP, Galimidi RP, Seaman MS, Freund NT, Nussenzweig MC, Bjorkman PJ.

Elife. 2017;6. pii: e27389

  1. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.

Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y.

Nature. 2017 Jul 6;547(7661):118-122.

  1. Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. 

Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H. 

Nat Struct Mol Biol. 2017;24(3):316-324

  1. Single-protein detection in crowded molecular environments in cryo-EM images. 

Rickgauer JP, Grigorieff N, Denk W. 

Elife. 2017;6. pii: e25648.

  1. Structure of the active form of human origin recognition complex and its ATPase motor module.

Tocilj A, On KF, Yuan Z, Sun J, Elkayam E, Li H, Stillman B, Joshua-Tor L.

Elife. 2017;6. pii: e20818. 

  1. Structural Titration of Slo2.2, a Na+-Dependent K+ Channel. 

Hite RK, MacKinnon R.

Cell. 2017;168(3):390-399.

  1. Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules. 

Liu D, Liu X, Shang Z, Sindelar CV.

Elife. 2017;6. pii: e24490.

  1. Cryo-electron tomography reveals novel features of a viral RNA replication compartment.

Ertel KJ, Benefield D, Castaño-Diez D, Pennington JG, Horswill M, den Boon JA, Otegui MS, Ahlquist P. 

Elife. 2017;6. pii: e25940.

  1. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface.

Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. 

J Mol Biol. 2017;429(12):1829-1839. 

  1. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. 

Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B.

J Virol. 2017;91(10). pii: e00175-17.

  1. Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator. 

Zhang Z, Chen J. 

Cell. 2016 Dec 1;167(6):1586-1597.

  1. Structural basis for gating the high-conductance Ca2+-activated K+ channel.

Hite RK, Tao X, MacKinnon R. 

Nature. 2016 Dec 14. doi: 10.1038/nature20775.

  1. Structure of the transporter associated with antigen processing trapped by herpes simplex virus. 

Oldham ML, Grigorieff N, Chen J.

Elife. 2016 Dec 9;5. pii: e21829. doi: 10.7554/eLife.21829.

  1. A near atomic structure of the active human apoptosome. 

Cheng TC, Hong C, Akey IV, Yuan S, Akey CW. 

Elife. 2016 Oct 4;5. pii: e17755.

  1. A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation. 

Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW.

Structure. 2016 Nov 16. pii: S0969-2126(16)30342-2.

  1. Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. 

Wang H, Cohen AA, Galimidi RP, Gristick HB, Jensen GJ, Bjorkman PJ. 

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7151-E7158.

  1. Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.

Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Ramesh M, Espina N, Sun M, Tutuncuoglu B, Madison-Antenucci S, Woolford JL Jr, Tong L, Frank J.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12174-12179.

  1. Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase.

Mazhab-Jafari MT, Rohou A, Schmidt C, Bueler SA, Benlekbir S, Robinson CV, Rubinstein JL.

Nature. 2016 Oct 24:1-5. doi: 10.1038

  1. Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM.

Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Espina N, Madison-Antenucci S, Tong L, Frank J. 

Protein Sci. 2016 Oct 17. doi: 10.1002/pro.3068.

  1. DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.

Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA.

Mol Cell. 2016 Sep 1;63(5):840-51.

  1. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation.

Hussain T, Llácer JL, Wimberly BT, Kieft JS, Ramakrishnan V. 

Cell. 2016 Sep 22;167(1):133-144.e13.

  1. Design of a hyperstable 60-subunit protein icosahedron.

Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. 

Nature. 2016 Jul 7;535(7610):136-9.

  1. Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio cholerae and are stabilized by a double signaling domain receptor DosM.

Briegel A, Ortega DR, Mann P, Kjær A, Ringgaard S, Jensen GJ.,

Proc Natl Acad Sci U S A. 2016;113(37):10412-7

  1. Ribosome•RelA structures reveal the mechanism of stringent response activation.

Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. 

Elife. 2016;5. pii: e17029. 

  1. Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM. 

Zhao Y, Chen S, Yoshioka C, Baconguis I, Gouaux E., 

Nature. 2016 doi: 10.1038/nature18961.

  1. Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.

Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI., 

Science. 2016, 353(6294):83-6. 

  1. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. 

Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA., 

Science. 2016, 351:867-71.

  1. Mechanism of NMDA Receptor Inhibition and Activation. 

Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E.,

Cell. 2016, 165:704-14.

  1. Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.

Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA, 

Elife. 2016, 5. pii: e14874.

  1. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. 

Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H, 

Nature, 2016,  doi: 10.1038/nature17679

  1. Architecture of the type IVa pilus machine. 

Chang YW, Rettberg LA, Treuner-Lange A, Iwasa J, Søgaard-Andersen L, Jensen GJ.

Science. 2016, 351(6278): aad2001.

  1. Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.

Yuan Z, Bai L, Sun J, Georgescu R, Liu J, O'Donnell ME, Li H; 

Nature Structural and Molecular Biology, 2016, 23:217-24

  1. A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. 

Oldham ML, Hite RK, Steffen AM, Damko E, Li Z, Walz T, Chen J; 

Nature, 2016, 529:537-40.

  1. Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel.

Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R; 

Nature, 2015, 527:198-203.

  1. Glycine receptor mechanism elucidated by electron cryo-microscopy.

Du J, Lü W, Wu S, Cheng Y, Gouaux E;

Nature, 2015, 526:224-9.

  1. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning.

Taylor DW, Zhu Y, Staals RH, Kornfeld JE, Shinkai A, van der Oost J, Nogales E, Doudna JA; 

Science, 2015,348:581-5.

  1. Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G. 

Li W, Liu Z, Koripella RK, Langlois R, Sanyal S, Frank J; 

Science Advances, 2015, 1(4). pii: e1500169.

  1. Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces. 

Gonen S, DiMaio F, Gonen T, Baker D; 

Science, 2015, 348:1365-8.

  1. Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6.

Grant T, Grigorieff N; 

Elife, 2015, 4:e06980.

  1. Electron cryotomography studies of maturing HIV-1 particles reveal the assembly pathway of the viral core.

Woodward CL, Cheng SN, Jensen GJ; 

J Virol, 2015,89:1267-77.

  1. Marine tubeworm metamorphosis induced by arrays of bacterial phage tail-like structures. 

Shikuma NJ, Pilhofer M, Weiss GL, Hadfield MG, Jensen GJ, Newman DK; 

Science, 2014, 343:529-33.

  1. Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling.

Briegel A, Ladinsky MS, Oikonomou C, Jones CW, Harris MJ, Fowler DJ, Chang YW, Thompson LK, Armitage JP, Jensen GJ; 

Elife, 2014, 3:e02151.

  1. Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center.

Koh CS, Brilot AF, Grigorieff N, Korostelev AA; 

Proc Natl Acad Sci U S A, 2014, 111(25):9139-44.

  1. Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations.

Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA;

Structure, 2014 Aug 5;22(8):1210-8.

  1. Structural basis for the prion-like MAVS filaments in antiviral innate immunity.

Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX; 

Elife, 2014,3:e01489.

  1. New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.

Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, Fowler DJ, Thompson LK, Falke JJ, Kiessling LL, Jensen GJ; 

Biochemistry, 2014, 53(10):1575-85.

  1. Structure of the ribosome with elongation factor G trapped in the pretranslocation state.

Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N;

Proc Natl Acad Sci U S A, 2013, 110(52):20994-9.