Representative Publications with data obtained at the facility
- FOXP3 recognizes microsatellites and bridges DNA through multimerization.
Wenxiang Zhang, Fangwei Leng, Xi Wang, Ricardo N. Ramirez, Jinseok Park, Christophe Benoist & Sun Hur.
Nature. 2023 November 29; doi.org/10.1038/s41586-023-06793-z - The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis.
Maria E. Falzone and Roderick MacKinnon.
PNAS. 2023 November 22; 120 (48) e2315011120; doi.org/10.1073/pnas.2315011120 - The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization. Wenshuai Wang, Benjamin Götte, Rong Guo & Anna Marie Pyle.
Nature Communications. 2023 November 11; 14, Article number: 7308 (2023); doi.org/10.1038/s41467-023-42982-0 - De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.
Zhen Chen, Momoko Shiozaki, Kelsey M. Haas, ..., Robyn M. Kaake, Ronald D. Vale, David A. Agard.
Cell. 2023 November 9; doi.org/10.1016/j.cell.2023.09.017 - Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Jiarui Song, Anne R. Gooding, Wayne O. Hemphill, Brittney D. Love, Anne Robertson, Liqi Yao, Leonard I. Zon, Trista E. North, Vignesh Kasinath, and Thomas R. Cech.
Science. 2023 September 21; Vol 381, Issue 6664, pp. 1331-1337; DOI: 10.1126/science.adh0059 - Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology.
Chang Sun, Hongtao Zhu, Sarah Clark & Eric Gouaux.
Nature volume 622, pages195–201 (2023). 2023 September 20; doi.org/10.1038/s41586-023-06556-w - Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Naotaka Tsutsumi, Zahra Masoumi, Sophie C. James, ..., Jacob Piehler, Ian S. Hitchcock, K. Christopher Garcia.
Cell. 2023 September 14; 186, 1–15; doi.org/10.1016/j.cell.2023.07.037 - Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen.
Katharine M. Wright, Sarah R. DiNapoli, Michelle S. Miller, P. Aitana Azurmendi, Xiaowei Zhao, Zhiheng Yu, Mayukh Chakrabarti, WuXian Shi, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou & Sandra B. Gabelli.
Nature Communications. 2023 August 21; 14, Article number: 5063 (2023); doi.org/10.1038/s41467-023-40821-w - Structure of C. elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Sarah Clark, Hanbin Jeong, Rich Posert, April Goehring, Eric Gouaux. bioRxiv. 2023 August 17; doi.org/10.1101/2023.08.16.553618 - Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Shengjie Feng, Cristina Puchades, Juyeon Ko, Hao Wu, Yifei Chen, Eric E. Figueroa, Shuo Gu, Tina W. Han, Brandon Ho, Tong Cheng, Junrui Li, Brian Shoichet, Yuh Nung Jan, Yifan Cheng & Lily Yeh Jan.
Nature Communications. 2023 August 12; Nature Communications 14; Article number: 4874 (2023); doi.org/10.1038/s41467-023-40410-x - Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Jiyuan Zhang, Weizhong Zeng, Yan Han, Wan-Ru Lee, Jen Liou, Youxing Jiang.
Molecular Cell. 2023 July 20; Volume 83; Issue 14 (2023); pgs 2524-2539.e7; doi.org/10.1016/j.molcel.2023.06.004. - Structural insights into intron catalysis and dynamics during splicing.
Ling Xu, Tianshuo Liu, Kevin Chung & Anna Marie Pyle.
Nature. 2023 July 17; doi.org/10.1038/s41586-023-06746-6 - Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants.
Dongxue Yang, Zhiyu Zhao, Emad Tajkhorshid, and Eric Gouaux.
PNAS. 2023 July 12; 120 (29) e2304602120; doi.org/10.1073/pnas.2304602120 - Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography.
Mohammed Kaplan, Yi-Wei Chang, Catherine M. Oikonomou, William J. Nicolas, Andrew I. Jewett, Stefan Kreida, Przemysław Dutka, Lee A. Rettberg, Stefano Maggi & Grant J. Jensen.
Nature Microbiology 8, pages1267–1279 (2023). 2023 June 22; doi.org/10.1038/s41564-023-01401-2 - The principles of peptide selection by the transporter associated with antigen processing [preprint].
James Lee, Michael L. Oldham, Victor Manon, Jue Chen.
bioRxiv. 2023 June 17; doi.org/10.1101/2023.06.16.545308 - Quantification of gallium cryo-FIB milling damage in biological lamellae.
Bronwyn A. Lucas and Nikolaus Grigorieff.
PNAS. 2023 May 22; 120 (23) e2301852120; doi.org/10.1073/pnas.2301852120 - The membrane electric field regulates the PIP2-binding site to gate the KCNQ1 channel.
Venkata Shiva Mandala and Roderick MacKinnon.
PNAS. 2023 May 16; 120 (21) e2301985120; doi.org/10.1073/pnas.2301985120 - Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface.
Maria E. Falzone and Roderick MacKinnon.
PNAS. 2023 May 12;120 (20) e2301121120; doi.org/10.1073/pnas.2301121120 - Lipid flipping in the omega-3 fatty-acid transporter.
Chi Nguyen, Hsiang-Ting Lei, Louis Tung Faat Lai, Marc J. Gallenito, Xuelang Mu, Doreen Matthies & Tamir Gonen.
Nature Communications 14, 2571 (2023). 2023 May 8; doi.org/10.1038/s41467-023-37702-7 - Membrane protein isolation and structure determination in cell-derived membrane vesicles.
Xiao Tao, Chen Zhao, and Roderick MacKinnon.
PNAS. 2023 April 25; 120 (18) e2302325120; doi.org/10.1073/pnas.2302325120 - The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins.
Alexandria N Miller, Patrick R Houlihan, Ella Matamala, Deny Cabezas-Bratesco, Gi Young Lee, Ben Cristofori-Armstrong, Tanya L Dilan, Silvia Sanchez-Martinez, Doreen Matthies, David E Clapham.
eLife. 2023 January 25; 12:e84477; doi.org/10.7554/eLife.84477 - Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.
J. Andrew N. Alexander, Liam J. Worrall, Jinhong Hu, Marija Vuckovic, Nidhi Satishkumar, Raymond Poon, Solmaz Sobhanifar, Federico I. Rosell, Joshua Jenkins, Daniel Chiang, Wesley A. Mosimann, Henry F. Chambers, Mark Paetzel, Som S. Chatterjee & Natalie C. J. Strynadka.
Nature. 2023 January 4; Nature volume 613, pages375–382 (2023); doi.org/10.1038/s41586-022-05583-3 - In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes.
Zhen Chen, Garrett A. Greenan, Momoko Shiozaki, Yanxin Liu, Will M. Skinner, Xiaowei Zhao, Shumei Zhao, Rui Yan, Zhiheng Yu, Polina V. Lishko, David A. Agard & Ronald D. Vale.
Nature Structural & Molecular Biology. 2023 January 2; 30, pages360–369 (2023). doi.org/10.1038/s41594-022-00861-0 - Multifunctional Protein A Is the Only Viral Protein Required for Nodavirus RNA Replication Crown Formation.
Johan A. den Boon, Hong Zhan, Nuruddin Unchwaniwala, Mark Horswil, Kailey Slavik, Janice Pennington, Amanda Navine, and Paul Ahlquist.
Viruses. 2022 Dec 3; 14(12), 2711; doi.org/10.3390/v14122711 - Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.
Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E. Wilkinson, Soumya Kannan, F. Esra Demircioglu, Rui Yan, Momoko Shiozaki, Zhiheng Yu, Kira S. Makarova, Eugene V. Koonin, Rhiannon K. Macrae & Feng Zhang.
Nature. 2022 October 12; 610, pages575–581. doi.org/10.1038/s41586-022-05324-6 - Structures of the TMC-1 complex illuminate mechanosensory transduction.
Hanbin Jeong, Sarah Clark, April Goehring, Sepehr Dehghani-Ghahnaviyeh, Ali Rasouli, Emad Tajkhorshid & Eric Gouaux.
Nature 610, 796-803 (2022). 2022 October 12; doi.org/10.1038/s41586-022-05314-8. - De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography.
Zhen Chen, Momoko Shiozaki, Kelsey M. Haas, Shumei Zhao, Caiying Guo, Benjamin J. Polacco, Zhiheng Yu, Nevan J. Krogan, Robyn M. Kaake, Ronald D. Vale, David A. Agard.
bioRxiv. 2022 September 29; doi.org/10.1101/2022.09.28.510016 - Organizing structural principles of the IL-17 ligand–receptor axis.
Steven C. Wilson, Nathanael A. Caveney, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M. Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler & K. Christopher Garcia.
Nature. 2022 July 21; Nature volume 609, pages622–629 (2022); doi.org/10.1038/s41586-022-05116-y - In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts.
Shujun Cai, Yumei Wu, Adres Guillen-Samander, and Piertro De Camilli.
PNAS. 2022 July 13; 119 (29) e2203769119; doi.org/10.1073/pnas.2203769119 - Allosteric interactions prime androgen receptor dimerization and activation.
Elizabeth V.Wasmuth, Arnaud Vanden Broeck, Justin R. LaClair,..., Susan T. Weintraub, Sebastian Klinge, Charles L.Sawyers.
Molecular Cell. 2022 June 2; 82,2021–2031; doi.org/10.1016/j.molcel.2022.03.035 - Structure of the IL-27 quaternary receptor signaling complex.
Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi, K Christopher Garcia.
eLife. 2022 May 17; 11:e78463; doi.org/10.7554/eLife.78463 - Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.
Lan Wang, Hannah Toutkoushian, Vladislav Belyy, Claire Y Kokontis, Peter Walter.
eLife. 2022 May 12; 11:e73941; doi.org/10.7554/eLife.73941 - Structural basis of NPR1 in activating plant immunity.
Shivesh Kumar, Raul Zavaliev, Qinglin Wu, Ye Zhou, Jie Cheng, Lucas Dillard, Jordan Powers, John Withers, Jinshi Zhao, Ziqiang Guan, Mario J. Borgnia, Alberto Bartesaghi, Xinnian Dong & Pei Zhou.
Nature. 2022 May 11; 605, pages561–566; doi.org/10.1038/s41586-022-04699-w - Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Nadine M. Shaban, Rui Yan, Ke Shi, Sofia N. Maraes, Reuben S. Harris.
Science Advances. 2022 April 27; Vol 8, Issue 17; DOI: 10.1126/sciadv.abm2827 - CENP-N promotes the compaction of centromeric chromatin.
Keda Zhou, Magdalena Gebala, Dustin Woods, Kousik Sundararajan, Garrett Edwards, Dan Krzizike, Jeff Wereszczynski, Aaron F. Straight & Karolin Luger.
Nature Structural & Molecular Biology. 2022 April 14; 29, pages403–413 (2022); doi.org/10.1038/s41594-022-00758-y - Structure of the human ATM kinase and mechanism of Nbs1 binding.
Christopher Warren, Nikola P. Pavletich.
eLife. 2022 January 25; doi.org/10.7554/eLife.74218 - Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography.
Johannes Elferich, Sarah Clark, Jingpeng Ge, April Goehring, Aya Matsui, Eric Gouaux.
eLife. 2021 December 29; doi.org/10.7554/eLife.74512 - Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2.
Akihito Fukudome, Jasleen Singh, Vibhor Mishra, and Craig S. Pikaard.
PNAS. 2021 Decemeber 13; 118 (51) e2115899118; doi.org/10.1073/pnas.2115899118 - A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Yongjian Huang, Jana Ognjenović, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan.
eLife. 2021 November 30; doi.org/10.7554/eLife.73218 - SMARCAD1 is an ATP-dependent histone octamer exchange factor with de novo nucleosome assembly activity.
Jonathan Markert, Keda Zhou, and Karolin Luger.
Science Advances. 2021 October 15; Vol 7, Issue 42; DOI: 10.1126/sciadv.abk2380 - The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease.
Aurelie de Rus Jacquet, Jenna L Tancredi, Andrew L Lemire, Michael C DeSantis, Wei-Ping Li, Erin K O'Shea.
eLife. 2021 September 30; doi.org/10.7554/eLife.73062 - Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.
Qin Cao, David R. Boyer, Michael R. Sawaya, Romany Abskharon, Lorena Saelices, Binh A. Nguyen, Jiahui Lu, Kevin A. Murray, Fouad Kandeel & David S. Eisenberg.
Nature Structural & Molecular Biology. 2021 September 9; Nat Struct & Mol Bio volume 28, pages724–730 (2021); doi.org/10.1038/s41594-021-00646-x - Molecular basis of cholesterol efflux via ABCG subfamily transporters
. Yingyuan Sun, Jin Wang, Tao Long, Xiaochun Li, (Contributed by Helen Hobbs).
PNAS. 2021 August 17; 118 (34) e2110483118; doi.org/10.1073/pnas.2110483118 - TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase.
Jing Xue, Yan Han, Hamid Baniasadi Weizhong Zeng, Jimin Pei, Nick V Grishin, Junmei Wang, Benjamin P Tu, Youxing Jiang.
eLife. 2021 August 10; doi.org/10.7554/eLife.71220 - Virus-encoded histone doublets are essential and form nucleosome-like structures.
Yang Liu, Hugo Bisio, Chelsea Marie Toner,...,Garrett Edwards, Chantal Abergel, Karolin Luger.
Cell. 2021 August 5; 184,4237–4250; doi.org/10.1016/j.cell.2021.06.032 - Structural mechanisms of gating and selectivity of human rod CNGA1 channel,
Jing Xue, Yan Han, Weizhong Zeng, Yan Wang, Youxing Jiang.
Neuron. 2021 April 21; Volume 109, Issue 8, 2021, pages 1302-1313.e4; doi.org/10.1016/j.neuron.2021.02.007. - Structure and function of the chromatin remodeler SMARCAD1 with its nucleosome substrate [preprint].
Jonathan Markert, Keda Zhou, Karolin Luger.
bioRxiv. 2021 April 14; doi.org/10.1101/2021.04.14.439859 - Structure of the p53/RNA polymerase II assembly.
Shu-Hao Liou, Sameer K. Singh, Robert H. Singer, Robert A. Coleman & Wei-Li Liu.
Communications Biology. 2021 March 25; 4, Article number: 397 (2021); doi.org/10.1038/s42003-021-01934-4 - Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Robert Saxton, Naotaka Tsutsumi, Leon L. Su, Gita C. Abhiraman, Kritika Mohan, Lukas T. Henneberg, Nanda G. Aduri, Cornelius Gati, and K Christopher Garcia.
Science. 2021 March 19; Vol 371, Issue 6535; DOI: 10.1126/science.abc8433 - Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport.
Biao Qui, Doreen Matthies, Eva Fortea, Zhiheng Yu, Olga Boudker.
Science Advances. 2021 March 3; Vol 7, Issue 10; DOI: 10.1126/sciadv.abf5814 - Mechanism of gating and partial agonist action in the glycine receptor.
Jie Yu, Hongtao Zhu, Remigijus Lape,..., Wei Lu¨, Lucia Sivilotti, Eric Gouaux.
Cell. 2021 February 18; 184,957–968; https://doi.org/10.1016/j.cell.2021.01.026. - Pre-termination Transcription Complex: Structure and Function.
Zhitai Hao, Vitaly Epshtein, Kelly H. Kim,..., Alexander Mironov, Thomas Walz, Evgeny Nudler.
Molecular Cell. 2021 January 21; 81,281–292; doi.org/10.1016/j.molcel.2020.11.013 - The structural basis of Rubisco phase separation in the pyrenoid.
Shan He, Hui-Ting Chou, Doreen Matthies, Tobias Wunder, Moritz T. Meyer, Nicky Atkinson, Antonio Martinez-Sanchez, Philip D. Jeffrey, Sarah A. Port, Weronika Patena, Guanhua He, Vivian K. Chen, Frederick M. Hughson, Alistair J. McCormick, Oliver Mueller-Cajar, Benjamin D. Engel, Zhiheng Yu & Martin C. Jonikas.
Nature Plants. 2020 November 23; Nature Plants volume 6, pages1480–1490 (2020); doi.org/10.1038/s41477-020-00811-y - Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
Guillaume Gaullier, Genevieve Roberts, Uma M. Muthurajan, Samuel Bowerman, Johannes Rudolph, Jyothi Mahadevan, Asmita Jha, Purushka S. Rae, Karolin Luger.
PLOS ONE. 2020 November 3; doi.org/10.1371/journal.pone.0240932 - Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Naotaka Tsutsumi, Somnath Mukherjeem Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, K Christopher Garcia.
eLife. 2020 August 7; eLife 9:e58464; doi.org/10.7554/eLife.58464 - Structure of human GABAB receptor in an inactive state.
Jinseo Park, Ziao Fu, Aurel Frangaj, Jonathan Liu, Lidia Mosyak, Tong Shen, Vesna N. Slavkovich, Kimberly M. Ray, Jaume Taura, Baohua Cao, Yong Geng, Hao Zuo, Yongjun Kou, Robert Grassucci, Shaoxia Chen, Zheng Liu, Xin Lin, Justin P. Williams, William J. Rice, Edward T. Eng, Rick K. Huang, Rajesh K. Soni, Brian Kloss, Zhiheng Yu, Jonathan A. Javitch, Wayne A. Hendrickson, Paul A. Slesinger, Matthias Quick, Joseph Graziano, Hongtao Yu, Oliver Fiehn, Oliver B. Clarke, Joachim Frank & Qing R. Fan.
Nature. 2020 June 24; 584, pages304–309 (2020); doi.org/10.1038/s41586-020-2452-0 - Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication.
Hong Zhan, Janice Pennington, Paul Ahlquist.
PNAS. 2020 June 9; 117 (31) 18680-18691; doi.org/10.1073/pnas.2006165117 - The structure of human CST reveals a decameric assembly bound to telomeric DNA.
Ci Ji Lim, Alexandra T. Barbour, Arthur J. Zaug, Allison E. McKay, Deborah S. Wuttke, Thomas R. Cech. Science. 2020 June 5; Vol 368, Issue 6495, pp. 1081-1085. DOI: 10.1126/science.aaz9649 - LetB Structure Reveals a Tunnel for Lipid Transport across the Bacterial Envelope.
Georgia L. Isom, Nicolas Coudray, Mark R. MacRae, Collin T. McManus, Damian C. Ekiert, Gira Bhabha.
Cell. 2020 April 30; 181,653–664; doi.org/10.1016/j.cell.2020.03.030 - Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex.
Xudong Wu, Marc Siggel, Sergey Ovchinnikov, Wei Mi, Vladimir Svetlov, Evgeny Nudler, Maofu Liao, Gerhard Hummer, and Tom A. Rapoport.
Science. 2020 April 24; Vol 368, Issue 6489; DOI: 10.1126/science.aaz2449. - Label-free single-instance protein detection in vitrified cells.
J. Peter Rickgauer, Heejun Choi, Jennifer Lippincott-Schwartz, Winfried Denk.
bioRxiv. 2020 April 24; doi.org/10.1101/2020.04.22.053868 - Molecular structures of the human Slo1 K+ channel in complex with β4.
Xiao Tao, Roderick MacKinnon.
eLife. 2019 December 9; doi.org/10.7554/eLife.51409 - Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex.
Anthony H. Nguyen, Alex R. B. Thomsen, Thomas J. Cahill III, Rick Huang, Li-Yin Huang, Tara Marcink, Oliver B. Clarke, Søren Heissel, Ali Masoudi, Danya Ben-Hail, Fadi Samaan, Venkata P. Dandey, Yong Zi Tan, Chuan Hong, Jacob P. Mahoney, Sarah Triest, John Little IV, Xin Chen, Roger Sunahara, Jan Steyaert, Henrik Molina, Zhiheng Yu, Amedee des Georges & Robert J. Lefkowitz.
Nature Structural & Molecular Biology. 2019 November 18; volume 26, pages1123–1131; doi.org/10.1038/s41594-019-0330-y - Structure-based inhibitors of amyloid beta core suggest a common interface with tau.
Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, David S Eisenberg.
eLife. 2019 October 15; 8:e46924; doi.org/10.7554/eLife.46924. - Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response.
Aditya A. Anand, Peter Walter.
The FEBS Journal. 2019 September 24; 287(2), 239-245; doi.org/10.1111/febs.15073 - Cryo-EM Studies ofT MEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Shengjie Feng, Shangyu Dang, Tina Wei Han,...,Yuh Nung Jan, Lily Yeh Jan,Yifan Cheng.
Cell Reports. 2019 July 9; 28,567–579; doi.org/10.1016/j.celrep.2019.06.023 - Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain.
Stefan Niekamp, Nicolas Coudray, Nan Zhang, Ronald D. Vale, Gira Bhadha.
The EMBO Journal. 2019 May 31; 38:e101414; doi.org/10.15252/embj.2018101414 - Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.
Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ.
Nat Struct Mol Biol. 2019 Dec;26(12):1123-1131. doi: 10.1038/s41594-019-0330-y.
Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM.
Cell. 2019 Nov 27;179(6):1319-1329.e8. doi: 10.1016/j.cell.2019.10.036.
Hu J, Worrall LJ, Vuckovic M, Hong C, Deng W, Atkinson CE, Brett Finlay B, Yu Z, Strynadka NCJ.
Nat Microbiol. 2019 Nov;4(11):2010-2019. doi: 10.1038/s41564-019-0545-z.
Majewski DD, Worrall LJ, Hong C, Atkinson CE, Vuckovic M, Watanabe N, Yu Z, Strynadka NCJ.
Nat Commun. 2019 Feb 7;10(1):626. doi: 10.1038/s41467-019-08477-7.
Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF.
Nature. 2019 Jan;565(7737):118-121. doi: 10.1038/s41586-018-0779-6.
Ghosal D, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ.
Nat Microbiol. 2019 Dec;4(12):2101-2108. doi: 10.1038/s41564-019-0603-6.
Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA.
Science. 2019 Aug 2;365(6452). pii: eaax1033. doi: 10.1126/science.aax1033.
Niekamp S, Coudray N, Zhang N, Vale RD, Bhabha G.
EMBO J. 2019 Jul 1;38(13):e101414. doi: 10.15252/embj.2018101414.
Ghosal D, Jeong KC, Chang YW, Gyore J, Teng L, Gardner A, Vogel JP, Jensen GJ.
Nat Microbiol. 2019 Jul;4(7):1173-1182. doi: 10.1038/s41564-019-0427-4.
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y.
Cell Rep. 2019 Jul 30;28(5):1385. doi: 10.1016/j.celrep.2019.07.052.
Zhang Y, Cheng TC, Huang G, Lu Q, Surleac MD, Mandell JD, Pontarotti P, Petrescu AJ, Xu A, Xiong Y, Schatz DG.
Nature. 2019 May;569(7754):79-84. doi: 10.1038/s41586-019-1093-7.
Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A.
Science. 2019 May 3;364(6439):491-495. doi: 10.1126/science.aaw2922.
Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J.
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8869-8878. doi: 10.1073/pnas.1820323116.
Greber BJ, Toso DB, Fang J, Nogales E.
Elife. 2019 Mar 12;8. pii: e44771. doi: 10.7554/eLife.44771.
- CryoEM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina.
Heymann JB, Vijayasarathy C, Huang RK, Dearborn AD, Sieving PA, Steven AC.
J Cell Biol. 2019 Mar 4;218(3):1027-1038. doi: 10.1083/jcb.201806148.
Wu X, Cabanos C, Rapoport TA.
Nature. 2019 Feb;566(7742):136-139. doi: 10.1038/s41586-018-0856-x.
Hu J, Worrall LJ, Hong C, Vuckovic M, Atkinson CE, Caveney N, Yu Z, Strynadka NCJ.
Nat Commun. 2018 Sep 21;9(1):3840. doi: 10.1038/s41467-018-06298-8.
Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM.
Nature. 2018 Apr 5;556(7699):64-69.
- Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH.
Nature. 2018. doi: 10.1038/s41586-018-0249-1.
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