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An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster

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bioRxiv. 2025 Jul;. doi: 10.1101/2025.02.22.639679
An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster Stern LabFlyLight
Zung JL, Namiki S, Meissner GW, Costa M, Eichler K, Stürner T, Jefferis GS, Managan C, Team FlyLight, Korff W, Card GM
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Abstract

Descending neurons (DNs) occupy a key position in the sensorimotor hierarchy, conveying signals from the brain to the rest of the body below the neck. In Drosophila melanogaster flies, approximately 480 DN cell types have been described from electron-microscopy image datasets. Genetic access to these cell types is crucial for further investigation of their role in generating behaviour. We previously conducted the first large-scale survey of Drosophila melanogaster DNs, describing 98 unique cell types from light microscopy and generating cell-type-specific split-Gal4 driver lines for 65 of them. Here, we extend our previous work, describing the morphology of 137 additional DN types from light microscopy, bringing the total number DN types identified in light microscopy datasets to 235, or nearly 50%. In addition, we produced 500 new sparse split-Gal4 driver lines and compiled a list of previously published DN lines from the literature for a combined list of 738 split-Gal4 driver lines targeting 171 DN types.

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Janelia Authors

Shigehiro Namiki
Geoffrey Meissner
Katharina Eichler
Claire Managan
Wyatt Korff
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