| Janelia Research Campus

FilaBuster: A Strategy for Rapid, Specific, and Spatiotemporally Controlled Intermediate Filament Disassembly

Moore AS, Krug T, Hansen SB, Ludlow AV, Grimm JB, Ayala AX, Plutkis SE, Wang N, Goldman RD, Medalia O et al.. 2025. FilaBuster: A Strategy for Rapid, Specific, and Spatiotemporally Controlled Intermediate Filament Disassembly. bioRxiv.

Abstract 2420: Deep learning enables automated detection of circulating tumor cell-immune cell interactions with prognostic insights in cancer

Sun Y, Squires JR, Hoffmann A, Zhang Y, Minor A, Singh A, Scholten D, Mao C, Luo Y, Fang D et al.. 2025. Abstract 2420: Deep learning enables automated detection of circulating tumor cell-immune cell interactions with prognostic insights in cancer. Cancer Research. 85:2420-2420.

Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering.

Nakamura K, Aoyama-Ishiwatari S, Nagao T, Paaran M, Obara CJ, Sakurai-Saito Y, Johnston J, Du Y, Suga S, Tsuboi M et al.. 2025. Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering.. Nat Commun. 16(1):3401.

Glutamate indicators with increased sensitivity and tailored deactivation rates

Podgorski K, Aggarwal A, Negrean A, Chen Y, Iyer R, Reep D, Liu A, Palutla A, Xie M, Maclennan B et al.. 2025. Glutamate indicators with increased sensitivity and tailored deactivation rates. Research Square.

Wnt/β-catenin signalling assists cell fate decision making in the early mouse embryo

Lilao-Garzón J, Corujo-Simon E, Vinyoles M, Fischer SC, Guillén J, Balayo T, Muñoz-Descalzo S. 2025. Wnt/β-catenin signalling assists cell fate decision making in the early mouse embryo. bioRxiv.

Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment.

Pentimalli TMassimo, Schallenberg S, León-Periñán D, Legnini I, Theurillat I, Thomas G, Boltengagen A, Fritzsche S, Nimo J, Ruff L et al.. 2025. Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment.. Cell Syst. :101261.

A Bayesian Model to Count the Number of Two-State Emitters in a Diffraction Limited Spot.

Hillsley A, Stein J, Tillberg PW, Stern DL, Funke J. 2025. A Bayesian Model to Count the Number of Two-State Emitters in a Diffraction Limited Spot.. Nano Lett.

Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals.

Mi X, Chen ABo-Yuan, Duarte D, Carey E, Taylor CR, Braaker PN, Bright M, Almeida RG, Lim J-X, Ruetten VMS et al.. 2025. Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals.. Cell.

Far-red fluorescent genetically encoded calcium ion indicators.

Dalangin R, Jia BZ, Qi Y, Aggarwal A, Sakoi K, Drobizhev M, Molina RS, Patel R, Abdelfattah AS, Zheng J et al.. 2025. Far-red fluorescent genetically encoded calcium ion indicators.. Nat Commun. 16(1):3318.

Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety.

Zhu Z, Gong R, Rodriguez V, Quach KT, Chen X, Sternson SM. 2025. Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety.. Science. 387(6741):eadt0773.