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    Atalanta plasmid technology
    The Atalanta technology is a significant genetic engineering advancement, simplifying cloning and improving the efficiency of  CRISPR-Cas9 induced homology-directed repair (HDR) for genome...
    Tools
    CaMPARI 2.0
    CaMPARI (Calcium Modulated Photoactivatable Ratiometric Integrator) is a photoconvertible protein construct that enables imaging of the integrated calcium activity of large populations of cells...
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    CASFISH: DNA labeling with CRISPR/Cas9
    Genomic DNA in cells is highly folded and organized in three dimensions. Detection and visualization of genomic DNA are widely accomplished by using various fluorescence in situ...
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    FLInChR
    FLInChR is an engineered variant of a light-gated opsin, Channelrhodopsin, that functions as a potent optical inhibitor of neuronal activity.  Fusion to the ‘leader’ sequence results in...
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    Glucose Sensor
    Inventors at Howard Hughes Medical Center's Janelia Research Campus have developed a strategy for creating genetically encoded, intensity-based fluorescent sensors and an associated unique set of...
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    iATPSnFR2
    The iATPSnFR2 is a next-generation ATP sensor that offers significant improvements over its predecessor, iATPSnFR1, for real-time tracking of ATP levels within subcellular compartments. By...
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    iGABASnFR2
    iGABASnFR2 is the current (2022) generation of GABA-Sensing Fluorescent Reporters developed at HHMI's Janelia Research Campus. Other sensor technologies such as SF-iGluSnFR, jGCaMP8, and...
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    iGluSnFR3
    iGluSnFR3 is the current (2022) generation of Glutamate-Sensing Fluorescent Reporters developed at HHMI's Janelia Research Campus to image the most abundant neurotransmitter in the mammal...
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    Janelia Fluor® Dyes
    Bright and photostable fluorescent labels are critical tools for the life sciences.  A key determinant of fluorophore performance is the quantum yield (QY); dyes with improved QY values are...
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    jASAP voltage indicators
    Progress in neuroscience demands the ability to record electrical activity optically in specifically tagged neurons in behaving animals. With that in mind, GENIE Project's accomplished researchers...